Picard: "Ensign, just because I happen to be sharing command with Dr. Crusher because most of the rest of the crew has been incapacitated is NOT a valid reason for calling our ship the Orville! Now stop snickering and set a course."
Pike: "Hold on. Spock, what the hell are we doing using laser pistols? Didn't phase pistols exist back in Captain Archer's time, but we're using only lasers now??"
"So, after thorough consideration, we're eliminating your job here on the Enterprise-E. We've determined that a bar is not necessary on the ship and… What the hell am I talking about?! Get your butt down to the NEW Ten Forward, Guinan!"
Joker: "Trick or treat! Smell my feet! Give me something good to eat! Ah ha! Ha! Ha! Haaaa!" (Bonus points if you read that in the voice of Mark Hamill's Joker)